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Etelcalcetide hydrochloride is a synthetic calcimimetic that activates the calcium sensing receptor (CaSR). It effectively lowers parathyroid hormone (PTH) concentrations in dialysis patients with secondary hyperparathyroidism, showing promise for research in this condition and chronic kidney disease.
Activates the calcium sensing receptor (CaSR).
Lowers parathyroid hormone (PTH) concentrations in dialysis patients.
Shows promise for research in secondary hyperparathyroidism and chronic kidney disease.
Dose-dependently reduces PTH levels in human parathyroid cells (in vitro).
Significantly reduces plasma PTH concentrations (in vivo).
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